For adults with chronic kidney disease in type 2 diabetes (CKD in T2D)

H is for How
KERENDIA Works

To understand how KERENDIA works, it helps to understand why chronic kidney disease in type 2 diabetes (CKD in T2D) may continue to progress over time.

There are 3 main factors that contribute to the progression of CKD

Icon of arrow with A1C text indicating rising A1C blood glucose levels

Poorly controlled glucose

Icon of blood pressure monitoring cuff

Poorly controlled blood pressure

Icon of kidney

Inflammation and scarring in the kidneys

How KERENDIA Works

While diabetes and high blood pressure medications may help control your glucose and blood pressure, KERENDIA is the only medication of its kind that blocks mineralocorticoid receptor (MR) overactivation in the kidneys, heart, and blood vessels.

This is important because MR overactivation may contribute to inflammation and scarring that can lead to progression of kidney disease. This may also worsen your cardiovascular disease. 

Blocking MRs is thought to slow the progression of CKD in T2D. So even if you are already taking medications for your diabetes and high blood pressure, there may be more that you can do to help delay the kidney damage from CKD.

What is MR overactivation, and how can KERENDIA help?

Having T2D can lead to overactivation of certain proteins, called MRs. When the MRs are overactivated, it may lead to inflammation and scarring in your kidneys, heart, and blood vessels. This is thought to lead to kidney damage that can lead to dialysis and kidney transplant, and may also worsen cardiovascular disease.

KERENDIA blocks the MRs. This prevents them from being overactive.

KERENDIA Patient Brochure

Read our brochure to learn more about CKD in T2D and KERENDIA.

View the Brochure

Doctor Discussion Guide

Get help starting a conversation with your doctor about whether treatment with KERENDIA may be right for you.

View the Discussion Guide

Sign Up to Learn More

Whether you’re just getting started with KERENDIA and are looking for support, or you need more information to decide if KERENDIA is right for you, our helpful emails will have you covered.

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What is KERENDIA?

KERENDIA is a prescription medicine used to treat chronic kidney disease in adults with type 2 diabetes to reduce the risk of:

  • Worsening of kidney disease
  • Kidney failure
  • Death due to cardiovascular disease
  • Heart attack
  • Hospitalization for heart failure

Important Safety Information

Do not take KERENDIA if you:
  • Have problems with your adrenal glands
  • Take certain medications called CYP3A4 inhibitors. Ask your healthcare provider if you are not sure if you are taking any of these medications
Before you take KERENDIA, tell your healthcare provider about all your medical conditions, including if you:
  • Have high potassium levels in your blood (hyperkalemia) or take medications that may increase potassium levels in your blood. KERENDIA can cause hyperkalemia. Your healthcare provider will check your potassium levels before and during treatment with KERENDIA
  • Have severe liver problems
  • Are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Avoid breastfeeding during treatment with KERENDIA and 1 day after treatment
Tell your healthcare provider about all the prescription and over-the-counter medicines you take, including: salt substitutes, vitamins, and herbal or potassium supplements.
  • KERENDIA may affect the way other medications work, and other medications may affect how KERENDIA works. Do not start or stop any medicine before you talk with your healthcare provider. Avoid grapefruit or grapefruit juice as it may increase KERENDIA levels in the blood
The most common side effects of KERENDIA include:
  • Hyperkalemia (potassium level in your blood that is higher than normal)
  • Hypotension (blood pressure that is lower than normal)
  • Hyponatremia (sodium level in your blood that is lower than normal)

Please see the Prescribing Information for KERENDIA.

Important Safety Information

Do not take KERENDIA if you:
  • Have problems with your adrenal glands
  • Take certain medications called CYP3A4 inhibitors. Ask your healthcare provider if you are not sure if you are taking any of these medications
Before you take KERENDIA, tell your healthcare provider about all your medical conditions, including if you:
  • Have high potassium levels in your blood (hyperkalemia) or take medications that may increase potassium levels in your blood. KERENDIA can cause hyperkalemia. Your healthcare provider will check your potassium levels before and during treatment with KERENDIA
  • Have severe liver problems
  • Are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Avoid breastfeeding during treatment with KERENDIA and 1 day after treatment
Tell your healthcare provider about all the prescription and over-the-counter medicines you take, including: salt substitutes, vitamins, and herbal or potassium supplements.
  • KERENDIA may affect the way other medications work, and other medications may affect how KERENDIA works. Do not start or stop any medicine before you talk with your healthcare provider. Avoid grapefruit or grapefruit juice as it may increase KERENDIA levels in the blood
The most common side effects of KERENDIA include:
  • Hyperkalemia (potassium level in your blood that is higher than normal)
  • Hypotension (blood pressure that is lower than normal)
  • Hyponatremia (sodium level in your blood that is lower than normal)

Please see the Prescribing Information for KERENDIA.