The efficacy and safety of KERENDIA to improve kidney and heart outcomes were evaluated in a study in adults with CKD in T2D. In this study, 5,674 patients were randomly assigned to receive either KERENDIA or a placebo.
KERENDIA doesn’t replace your diabetes and high blood pressure medications, so even if you are already taking medications for your diabetes and high blood pressure, there may be more you can do to help protect your kidneys and delay the damage that can lead to dialysis and kidney transplant.
KERENDIA is a once-daily tablet proven to slow the loss of kidney function and reduce the risk of kidney failure in adults with CKD in T2D.
To understand how KERENDIA works, it helps to understand why CKD in T2D may continue to progress over time. There are 3 main factors that contribute to the progression of CKD:
While diabetes and high blood pressure medications may help control your glucose and blood pressure, KERENDIA is the only medication of its kind that blocks mineralocorticoid receptor (MR) overactivation in the kidneys, heart, and blood vessels. MR overactivation may contribute to inflammation and scarring that can lead to progression of kidney disease. This may also worsen your cardiovascular disease.
Blocking MRs is thought to slow the progression of CKD in T2D. So even if you are already taking medications for your diabetes and high blood pressure, there may be more that you can do to help delay the kidney damage from CKD.
Having T2D can lead to overactivation of certain proteins, called MRs. When the MRs are overactivated, it may lead to inflammation and scarring in your kidneys, heart, and blood vessels. This is thought to lead to kidney damage that can lead to dialysis and kidney transplant. KERENDIA blocks the MRs. This prevents them from being overactive.
If you have type 2 diabetes and you’re starting to explore treatment options for your CKD in T2D, talking with your doctor may feel a bit overwhelming.
eGFR=estimated glomerular filtration rate; UACR=urine albumin-to-creatinine ratio.
KERENDIA is a prescription medicine used to treat chronic kidney disease in adults with type 2 diabetes to reduce the risk of:
Please see the Prescribing Information for KERENDIA.