How can KERENDIA help?

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KERENDIA can help slow the progression of chronic kidney disease (CKD) and lower the risk of cardiovascular complications in adults with CKD in type 2 diabetes (T2D)

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A large clinical study* demonstrated that KERENDIA is proven to:
  • Slow the loss of kidney function
  • Reduce the risk of kidney failure
How can KERENDIA help?
In the same clinical study,* KERENDIA also lowered the risk of:
  • Having a heart attack
  • Cardiovascular death
  • Hospitalization for heart failure

The efficacy and safety of KERENDIA to improve kidney and heart outcomes were evaluated in a study in adults with CKD in T2D. In this study, 5,674 patients were randomly assigned to receive either KERENDIA or a placebo.

In adults with CKD in T2D, KERENDIA fights CKD differently than your diabetes medications

KERENDIA doesn’t replace your diabetes and high blood pressure medications, so even if you are already taking medications for your diabetes and high blood pressure, there may be more you can do to help protect your kidneys and delay the damage that can lead to dialysis and kidney transplant.

KERENDIA is a once-daily tablet proven to slow the loss of kidney function and reduce the risk of kidney failure in adults with CKD in T2D.

How does KERENDIA work?

To understand how KERENDIA works, it helps to understand why CKD in T2D may continue to progress over time. There are 3 main factors that contribute to the progression of CKD:

  • Poorly controlled glucose
  • Poorly controlled blood pressure
  • Inflammation and scarring in the kidneys

While diabetes and high blood pressure medications may help control your glucose and blood pressure, KERENDIA is the only medication of its kind that blocks mineralocorticoid receptor (MR) overactivation in the kidneys, heart, and blood vessels. MR overactivation may contribute to inflammation and scarring that can lead to progression of kidney disease. This may also worsen your cardiovascular disease.

Blocking MRs is thought to slow the progression of CKD in T2D. So even if you are already taking medications for your diabetes and high blood pressure, there may be more that you can do to help delay the kidney damage from CKD.

What is MR overactivation, and how can KERENDIA help?

Having T2D can lead to overactivation of certain proteins, called MRs. When the MRs are overactivated, it may lead to inflammation and scarring in your kidneys, heart, and blood vessels. This is thought to lead to kidney damage that can lead to dialysis and kidney transplant. KERENDIA blocks the MRs. This prevents them from being overactive.

MR overactivation leading to inflammation KERENDIA attaching to the MR KERENDIA blocks the MR overactivation

Starting a conversation with your doctor

If you have type 2 diabetes and you’re starting to explore treatment options for your CKD in T2D, talking with your doctor may feel a bit overwhelming.

Here are a few questions that can help you prepare for your conversation with your doctor:
  • Has my kidney function worsened since my last visit?
  • Could KERENDIA slow the worsening of my CKD in T2D?
  • Will I see a change in my eGFR and UACR tests?
  • What possible side effects should I look out for?
  • How long will I need to take KERENDIA?
  • Can I take KERENDIA with my other medications?

eGFR=estimated glomerular filtration rate; UACR=urine albumin-to-creatinine ratio.

Ask your doctor how KERENDIA can slow the progression of kidney disease and reduce the risk of heart attack and hospitalization for heart failure in adults with CKD in T2D

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KERENDIA Doctor Discussion Guide

Is KERENDIA right for you? Using this discussion guide with your doctor can help start a conversation about how to manage your CKD in T2D.

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We're here to help

For questions about KERENDIA, financial support for your KERENDIA prescription, or patient support programs, please call 1-888-KERENDIA (537-3634).

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What is KERENDIA?

KERENDIA is a prescription medicine used to treat chronic kidney disease in adults with type 2 diabetes to reduce the risk of:

  • Worsening of kidney disease
  • Kidney failure
  • Death due to cardiovascular disease
  • Heart attack
  • Hospitalization for heart failure

Important Safety Information

Do not take KERENDIA if you:
  • Have problems with your adrenal glands
  • Take certain medications called CYP3A4 inhibitors. Ask your healthcare provider if you are not sure if you are taking any of these medications
Before you take KERENDIA, tell your healthcare provider about all your medical conditions, including if you:
  • Have high potassium levels in your blood (hyperkalemia) or take medications that may increase potassium levels in your blood. KERENDIA can cause hyperkalemia. Your healthcare provider will check your potassium levels before and during treatment with KERENDIA
  • Have severe liver problems
  • Are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Avoid breastfeeding during treatment with KERENDIA and 1 day after treatment
Tell your healthcare provider about all the prescription and over-the-counter medicines you take, including: salt substitutes, vitamins, and herbal or potassium supplements.
  • KERENDIA may affect the way other medications work, and other medications may affect how KERENDIA works. Do not start or stop any medicine before you talk with your healthcare provider. Avoid grapefruit or grapefruit juice as it may increase KERENDIA levels in the blood
The most common side effects of KERENDIA include:
  • Hyperkalemia (potassium level in your blood that is higher than normal)
  • Hypotension (blood pressure that is lower than normal)
  • Hyponatremia (sodium level in your blood that is lower than normal)

Please see the Prescribing Information for KERENDIA.