For adults with chronic kidney disease in type 2 diabetes (CKD in T2D)

F is for Frequently
Asked
Questions

Let’s answer some questions you may have about KERENDIA and chronic kidney disease in type 2 diabetes (CKD in T2D). Remember, your doctor is always the best resource for questions about your treatment and whether KERENDIA is right for you. If you don’t find the information you’re looking for below, you can also give us a call at 1-888-KERENDIA (537-3634).

Most popular questions

    KERENDIA is a once-daily prescription medicine used to treat chronic kidney disease in adults with type 2 diabetes to reduce the risk of:

    • Worsening of kidney disease
    • Kidney failure
    • Death due to cardiovascular disease
    • Heart attack
    • Hospitalization for heart failure

    View the KERENDIA Patient Brochure to learn more.

    The most common side effects of KERENDIA include:

    • Hyperkalemia (potassium level in your blood that’s higher than normal)
    • Hypotension (blood pressure that’s lower than normal)
    • Hyponatremia (sodium level in your blood that’s lower than normal)

    Chronic kidney disease in type 2 diabetes (CKD in T2D) is a progressive disease that affects the kidneys of adults with type 2 diabetes. CKD involves damage to the kidneys which can result in a gradual loss of kidney function over time. This damage can be permanent and may result in kidney failure. If the kidneys fail, dialysis or a kidney transplant may be required. Often, CKD doesn’t cause noticeable symptoms until the later stages, so it’s possible to have CKD and not know it.

    CKD in T2D can also lead to other serious health problems. For example, people with CKD in T2D are 3 times more likely to die from a cardiovascular event such as a heart attack, than people who have T2D alone. Learn more about CKD in T2D.

    Questions about CKD in T2D

      The disease is called chronic because the damage to your kidneys happens over a period of time, and because it’s a progressive disease, it means it gets worse over time. Chronic kidney disease does not go away and the damage to your kidneys cannot be reversed.

      CKD causes damage to the kidneys and reduces their ability to do their job. This puts more stress on the heart. People with CKD have an increased risk of cardiovascular complications like heart attack. Learn more about the connection between your kidneys and cardiovascular risk and talk to your doctor about how KERENDIA may help.

      Yes, it’s possible. Chronic kidney disease often doesn’t show symptoms until the later stages. One of the earliest indicators of CKD is protein in the urine, which happens when protein leaks into the urine through damaged filters in the kidneys. Doctors may refer to this as having “leaky kidneys.” If you have type 2 diabetes, talk with your doctor about your risk for CKD and getting a UACR (urine albumin-to-creatinine ratio) urine test to detect protein in your urine.

      CKD often does not show symptoms until later stages of the disease. By that time, symptoms are usually an indication of severe damage to the kidneys. Symptoms of later stage CKD can include the following:

      • Losing weight
      • Loss of appetite
      • Water retention that results in swelling of the ankles, feet, or hands 
      • Fatigue
      • Shortness of breath
      • Blood in your pee (urine)
      • Needing to pee more often, especially at night
      • Trouble sleeping
      • Itchy skin
      • Muscle cramps
      • Headaches

      Questions about KERENDIA

        For help starting a conversation with your doctor about your CKD in T2D and whether KERENDIA could be right for you, view our Doctor Discussion Guide.

        The first step is talking to your doctor to see if KERENDIA is right for you.

        Before starting on KERENDIA, you’ll have some blood work done to check the potassium levels in your blood and do an eGFR test to check your level of kidney function. This helps your doctor know what dose to prescribe.

        After starting KERENDIA, your doctor will work with you to schedule your lab work, which includes checking your potassium levels, and adjust your dose as needed.

        For more information about getting started with KERENDIA, view the Getting Started Guide.

        Questions about taking KERENDIA

          It’s important to take KERENDIA as prescribed:

          • KERENDIA is a once-daily oral tablet. You should swallow the tablet whole.
          • If you are unable to swallow a whole tablet, KERENDIA may be crushed and mixed with water or soft foods such as applesauce immediately prior to use and taken orally.
          • If you miss a dose of KERENDIA, take your prescribed dose as soon as you remember before the next scheduled dose. Do not take 2 doses on the same day to make up for a missed dose.
          • Take KERENDIA as prescribed and do not start or stop any medicine before talking with your doctor, including your diabetes and high blood pressure medications. Check with your doctor or pharmacist if you’re not sure.
          • Tell your healthcare provider about all the prescription and over-the-counter medicines you take, including: salt substitutes, vitamins, and herbal or potassium supplements. KERENDIA may affect the way other medications work, and other medications may affect how KERENDIA works. Do not start or stop any medicine before you talk with your healthcare provider. Avoid grapefruit or grapefruit juice as it may increase KERENDIA levels in the blood.

          If you miss a dose of KERENDIA, take your prescribed dose as soon as you remember before the next scheduled dose. Do not take 2 doses on the same day to make up for a missed dose.

          Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, salt substitutes, vitamins, and herbal or potassium supplements. KERENDIA may affect the way other medicines work, and other medicines may affect how KERENDIA works. Take KERENDIA as prescribed and do not start or stop any medicine before talking with your doctor, including your diabetes and high blood pressure medications.

          Do not take KERENDIA if you take certain medications called CYP3A4 inhibitors. Ask your healthcare provider if you are not sure if you are taking any of these.

          Your doctor is the best resource for any questions about your treatment plan. They will be able to tell you how long you should take KERENDIA. If you need to stop treatment with KERENDIA for any reason, always do so at the direction of your doctor.

          If you experience any side effects, you should notify your doctor immediately. Your doctor may change your dose if needed.

          Call your healthcare provider for medical advice about side effects. Additionally, you may report side effects to the FDA at 1-800-FDA-1088. Do not stop taking KERENDIA without speaking with your doctor.

          Store KERENDIA at room temperature between 68°F to 77°F (20°C to 25°C).

          Questions about savings and support

            Eligible patients may pay as little as $0 per month for KERENDIA.* Learn more about the KERENDIA Savings Card and available financial support programs here.

            *Patients are eligible if they are commercially insured and may pay as little as $0 per month. Benefit limitations apply. Patients who are enrolled in any type of government insurance or reimbursement programs are not eligible. Full terms and conditions apply, see KERENDIA.com/copay.

            BlinkRx is a digital pharmacy that looks for, and applies, available savings. After you register and check out, BlinkRx will also have your KERENDIA prescription delivered to your home with no delivery charge. You can ask your doctor to send your prescription to BlinkRx. Call 1-866-839-0766 for help transferring your prescription. Once your prescription has been transferred, you will receive a text message from BlinkRx with a link to register and pay for your prescription. Call 1-866-839-0766 or visit BlinkRx.com to learn more.

            In order to find out the cost of your prescription, you will need to have your prescription sent to or transferred to BlinkRx. Once you have registered and entered information about your insurance, BlinkRx will apply available savings programs and show you your cost. You can then choose to proceed to checkout or have your prescription transferred to a different pharmacy of your choice. You can ask your doctor to send your prescription to BlinkRx or you can call BlinkRx at 1-866-839-0766 for assistance.

            You can ask your physician or BlinkRx to transfer your prescription to another pharmacy at any time. The only exception to this, is if you are a patient with government insurance (e.g., Medicare, Medicaid, TRICARE or other federal or state health programs) who has agreed to participate in the $99 Self Pay program, opting out of using your government insurance for KERENDIA. If you have questions about this program or would like additional information, please call BlinkRx at 1-866-839-0766 to learn more.

            If you do not have insurance, your insurance plan does not cover KERENDIA, or you cannot afford your plan’s copay, you can choose to pay for your prescription yourself, without going through your insurance. KERENDIA is available for $99* per month through BlinkRx. BlinkRx is a digital pharmacy that will have your prescription delivered right to your door with no delivery charge. To use this option, ask your doctor to send your prescription to BlinkRx or call 1-866-839-0766 for help transferring your prescription. Once your prescription has been transferred, you will receive a text message from BlinkRx with a link to register and pay for your prescription, or you may complete the checkout process by phone. Call 1-866-839-0766 or visit BlinkRx.com to learn more. 

            *Terms and Conditions apply

            Patients who have chosen to enroll in the $99 Self Pay program have agreed to exclusively utilize this program for their KERENDIA prescription needs until the end of 2024. This means that prescriptions filled under this program cannot be transferred back to other pharmacies. If you have any questions about this program, please call 1-866-839-0766.

            The National Kidney Foundation
            Learn more about CKD in T2D and resources available to you.

            Centers for Disease Control and Prevention CKD Risk Calculators
            Check out these handy tools to calculate your risk of developing CKD, and the risk of progression to kidney failure if you already have CKD.

            American Association of Kidney Patients
            You’ll find lots of information, resources, and patient support here.

            National Institute of Diabetes and Digestive and Kidney Diseases
            If you want more detailed information about CKD and how to manage it, you’ll find it at this website.

            Know Diabetes By Heart
            Learn more about T2D and related resources available to you.

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            What is KERENDIA?

            KERENDIA is a prescription medicine used to treat chronic kidney disease in adults with type 2 diabetes to reduce the risk of:

            • Worsening of kidney disease
            • Kidney failure
            • Death due to cardiovascular disease
            • Heart attack
            • Hospitalization for heart failure

            Important Safety Information

            Do not take KERENDIA if you:
            • Have problems with your adrenal glands
            • Take certain medications called CYP3A4 inhibitors. Ask your healthcare provider if you are not sure if you are taking any of these medications
            Before you take KERENDIA, tell your healthcare provider about all your medical conditions, including if you:
            • Have high potassium levels in your blood (hyperkalemia) or take medications that may increase potassium levels in your blood. KERENDIA can cause hyperkalemia. Your healthcare provider will check your potassium levels before and during treatment with KERENDIA
            • Have severe liver problems
            • Are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Avoid breastfeeding during treatment with KERENDIA and 1 day after treatment
            Tell your healthcare provider about all the prescription and over-the-counter medicines you take, including: salt substitutes, vitamins, and herbal or potassium supplements.
            • KERENDIA may affect the way other medications work, and other medications may affect how KERENDIA works. Do not start or stop any medicine before you talk with your healthcare provider. Avoid grapefruit or grapefruit juice as it may increase KERENDIA levels in the blood
            The most common side effects of KERENDIA include:
            • Hyperkalemia (potassium level in your blood that is higher than normal)
            • Hypotension (blood pressure that is lower than normal)
            • Hyponatremia (sodium level in your blood that is lower than normal)

            Please see the Prescribing Information for KERENDIA.

            Important Safety Information

            Do not take KERENDIA if you:
            • Have problems with your adrenal glands
            • Take certain medications called CYP3A4 inhibitors. Ask your healthcare provider if you are not sure if you are taking any of these medications
            Before you take KERENDIA, tell your healthcare provider about all your medical conditions, including if you:
            • Have high potassium levels in your blood (hyperkalemia) or take medications that may increase potassium levels in your blood. KERENDIA can cause hyperkalemia. Your healthcare provider will check your potassium levels before and during treatment with KERENDIA
            • Have severe liver problems
            • Are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Avoid breastfeeding during treatment with KERENDIA and 1 day after treatment
            Tell your healthcare provider about all the prescription and over-the-counter medicines you take, including: salt substitutes, vitamins, and herbal or potassium supplements.
            • KERENDIA may affect the way other medications work, and other medications may affect how KERENDIA works. Do not start or stop any medicine before you talk with your healthcare provider. Avoid grapefruit or grapefruit juice as it may increase KERENDIA levels in the blood
            The most common side effects of KERENDIA include:
            • Hyperkalemia (potassium level in your blood that is higher than normal)
            • Hypotension (blood pressure that is lower than normal)
            • Hyponatremia (sodium level in your blood that is lower than normal)

            Please see the Prescribing Information for KERENDIA.