Important Safety Information

Do not take KERENDIA if you:

• Have problems with your adrenal glands
• Take certain medications called CYP3A4 inhibitors. Ask your healthcare provider if you are not sure if you are taking any of these medications

Before you take KERENDIA, tell your healthcare provider about all your medical conditions, including if you:

• Have high potassium levels in your blood (hyperkalemia) or take medications that may increase potassium levels in your blood. KERENDIA can cause hyperkalemia. Your healthcare provider will check your potassium levels before and during treatment with KERENDIA
• Have severe liver problems
• Are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Avoid breastfeeding during treatment with KERENDIA and 1 day after treatment

Tell your healthcare provider about all the prescription and over-the-counter medicines you take, including: salt substitutes, vitamins, and herbal or potassium supplements.

• KERENDIA may affect the way other medications work, and other medications may affect how KERENDIA works. Do not start or stop any medicine before you talk with your healthcare provider. Avoid grapefruit or grapefruit juice as it may increase KERENDIA levels in the blood

The most common side effects of KERENDIA include:

• Hyperkalemia (potassium level in your blood that is higher than normal)
• Hypotension (blood pressure that is lower than normal)
• Hyponatremia (sodium level in your blood that is lower than normal)

Please see the Prescribing Information for KERENDIA.